Well you can write CLR console apps, windows apps and such to make games using VS 2008. You just have to make a project and write code for the game.
You can use any of the languages in the .NET family. VC++, C#, VB.NET etc. They all handle graphics, can respond to user controls, animated sprites, and more.
The VS integrates well with XNA which is Microsoft's gaming development platform. You can go to many game programming websites in search of XNA tutorials and such that can give you a good start. However, it is STRONGLY recommended that you first learn how to write basic applications in your language of choice first before attempting a game. Games can be demanding on your time and on your skillset. If you don't know much about the language to begin with, you will struggle to understand game programming concepts and examples.
Learn the language first, then tackle a "small" game. And I am sure you will be on your way to making a blockbuster. Below is a nice site to bookmark for game programming resources...
Gamedev.netThe other resource is the game programming forum right here on DIC.