private void cmdUpload_Click(object sender, EventArgs e)
{
    DirectoryInfo directory = new DirectoryInfo(txtDirectory.Text);
    string uploadURL = "mypagetohandleuploads";
    string response = string.Empty;
    try
    {
        //Create a WebClient object
        WebClient client = new WebClient();
        
        //create network credentials
        NetworkCredential credentials = new NetworkCredential("myusername", "mypassword", "mydomain");

        //create a credentials cache
        CredentialCache cache = new CredentialCache();
        //add our credentials to our cache
        cache.Add(new Uri(@"myurl"), "Basic", credentials);
        
        //set the credentials for our WebClient
        client.Credentials = cache;

        //loop through each of the files in our directory
        foreach (FileInfo file in directory.GetFiles())
        {
            //Create a byte array and set it equal to the response returned by the
            //WebClient upload file method.
            byte[] res = client.UploadFile(uploadURL, "POST", directory + "\\" + file.Name);

            // Decode and store the response.
            response += (Encoding.ASCII.GetString(res));
            rtbStatus.Text += response;
        }
    }
    catch (Exception ex)
    {
        MessageBox.Show("Error trying to upload file: " + ex.Message, "Upload Error");
    }
}

protected void Page_Load(object sender, EventArgs e)
{
    string tempFileName = null;
    HttpFileCollection files = Request.Files;
    try
    {
        for (int i = 0; i < files.Count; i++)
        {
            tempFileName = Server.MapPath("~/images/tagz/completed/") + files[i].FileName.Substring(files[i].FileName.LastIndexOf("\\") + 1); ;//@"myuploadpath" + files[i].FileName.Substring(files[i].FileName.LastIndexOf("\\") + 1);
            files[0].SaveAs(tempFileName);
        }
    }
    catch (Exception ex)
    {
        SqlManager sql = new SqlManager();
        string ip = System.Web.HttpContext.Current.Request.UserHostAddress.ToString();
        string message = ex.Message.ToString();
        int eventType = 3;
        string username = "angelzdesigns.com_fp";
        sql.LogSystemEvent(ref eventType, ref message, ref ip, ref username);
    }
}

WebRequest wr = WebRequest.Create(@"myurl");
//should be your NetworkCredential
wr.Credentials = credentials; 

private void cmdUpload_Click(object sender, EventArgs e)
{
    DirectoryInfo directory = new DirectoryInfo(txtDirectory.Text);
    string uploadURL = "** Removed For Security **";
    string response = string.Empty;
    try
    {
        //Create a WebClient object
        WebClient client = new WebClient();

        //create network credentials
        NetworkCredential credentials = new NetworkCredential("** Removed **", "** Removed **");

        //create a credentials cache
        CredentialCache cache = new CredentialCache();

        //add our credentials to our cache
        cache.Add(new Uri(uploadURL), "Basic", credentials);

        //set the credentials for our WebClient
        client.Credentials = cache;

        client.Headers.Add("Content-Type", "application/x-www-form-urlencoded");
        client.Headers.Add("CharSet", "UTF-8");

        //loop through each of the files in our directory
        foreach (FileInfo file in directory.GetFiles("*.gif"))
        {
            byte[] array = Encoding.ASCII.GetBytes(directory + "\\" + file.Name);

            //Create a byte array and set it equal to the response returned by the
            //WebClient upload data method.                    
            byte[] res = client.UploadData(uploadURL, array);

            // Decode and store the response.
            response = (Encoding.ASCII.GetString(res));
            rtbStatus.Text += response;
        }
    }
    catch (Exception ex)
    {
        MessageBox.Show("Error trying to upload file: " + ex.Message, "Upload Error");
    }
}

protected void Page_Load(object sender, EventArgs e)
{
    HttpFileCollection files = Request.Files;
    try
    {
        for (int i = 0; i < files.Count; i++)
        {
            string file = files[i].FileName.Substring(files[i].FileName.LastIndexOf("\\") + 1);
            files[0].SaveAs(Server.MapPath("~/images/tagz/completed/") + file);
        }
    }
    catch (Exception ex)
    {
        SqlManager sql = new SqlManager();
        string ip = System.Web.HttpContext.Current.Request.UserHostAddress.ToString();
        string message = ex.Message.ToString();
        int eventType = 3;
        string username = "** Removed **";
        sql.LogSystemEvent(ref eventType, ref message, ref ip, ref username);
    }
}

public void UploadFile(ref string file, ref string url)
{
    HttpWebRequest request = (HttpWebRequest)WebRequest.Create(url);

    request.Method = "GET";
    request.ContentType = "multipart/form-data";
    request.AllowWriteStreamBuffering = true;

    //create network credentials
    NetworkCredential credentials = new NetworkCredential("** REMOVED **", "** REMOVED **");

    //create a credentials cache
    CredentialCache cache = new CredentialCache();

    //add our credentials to our cache
    cache.Add(new Uri(url), "Basic", credentials);

    //set the credentials for our WebClient
    request.Credentials = credentials;

    //Retrieve request stream 
    Stream requestStream = request.GetRequestStream();

    // Open the local file
    FileStream stream = new FileStream(file, FileMode.Create);

    // Allocate byte buffer to hold file contents
    byte[] data = new byte[4096];

    // loop through the local file reading each data block
    //  and writing to the request stream buffer
    int size = stream.Read(data, 0, data.Length);
    while (size > 0)
    {
        request.ContentLength = data.Length;
        requestStream.Write(data, 0, size);
        size = stream.Read(data, 0, data.Length);
    }

    stream.Close();
    requestStream.Close();

    request.GetResponse();
}