[brickman619]

Im working on a program in VB 2012. I want to make it so that when a picture box is clicked, its picture changes to another picture. When its clicked again, its picture changes back to the original.

[torind_2000]

you do it with the click event

something like

    Private Sub PictureBox1_Click(sender As Object, e As System.EventArgs) Handles PictureBox1.Click
        PictureBox1.Image = New Bitmap("c:\Users\Public\Pictures\Sample Pictures\hydrangeas.jpg")
    End Sub

    Private Sub MainForm_Load(sender As Object, e As System.EventArgs) Handles Me.Load
        PictureBox1.Image = New Bitmap("C:\Users\Public\Pictures\Sample Pictures\tulips.jpg")
    End Sub

    Private Sub PictureBox1_MouseDoubleClick(sender As Object, e As System.Windows.Forms.MouseEventArgs) Handles PictureBox1.MouseDoubleClick
        PictureBox1.Image = New Bitmap("C:\Users\Public\Pictures\Sample Pictures\tulips.jpg")

this isn't exactly what you're looking for, but it's a start

[CharlieMay]

I've done something similar using the tag property of the picturebox.
at design time, I set the tag to 0

Then in the Click event of the picturebox I used

If pbToggle.Tag.ToString = "0" then
  'Set the image to the one you want on the initial click
  pbToggle.Tag = "1" 'now set the tag to 1 so the next picture shows on next click
Else
  'Set the image to the other picture
  pbToggle.Tag = "0"
End If

so with each click the tag is so that the next click is the opposite image.