Its the old file permissions issue however, no matter how I set the file permissions on the folder where the .mdb file is located, I still cannot open the file for write access.
I desperation I even tried setting the directory security user to the local Administrator account, still the same ...
stopped and restarted iis after changes, etc ...
two different IIS 6 servers tried, identical issue on both
Run out of option now

The site works without issue when run through VS2010 dev server
Help !